Assay Detail
Functional
CHEMBL1065680
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Antagonist activity at human P2Y2 receptor expressed in astrocytoma cells assessed as inhibition of intracellular calcium mobilization
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.12 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223344 | RB 2 | — | 1 | 5.73 |
| CHEMBL496030 | — | — | 1 | 5.33 |
| CHEMBL498423 | — | — | 1 | 5.18 |
| CHEMBL608559 | — | — | 1 | 5.00 |
| CHEMBL256057 | ACID BLUE 25 | — | 1 | 4.96 |
| CHEMBL590956 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223344 | RB 2 | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL496030 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL498423 | — | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL608559 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL256057 | ACID BLUE 25 | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL590956 | — | IC50 | = | 29900.0 | nM | 4.52 |