Assay Detail

CHEMBL1065926

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Binding

Inhibition of calf thymus DNA topoisomerase 1 assessed as pUC19 DNA relaxation by gel electrophoresis

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bos taurus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L.

Diwan R, Malpathak N.
Bioorg Med Chem (2009) 17 : 7052 -7055
PubMed 19736019 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	4.90	5.19
Inhibition	3	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL24171	BERGAPTEN	3.0	2	5.19
CHEMBL164660	PSORALEN	1.0	2	4.96
CHEMBL416	METHOXSALEN	4.0	2	4.55

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL24171	BERGAPTEN	IC50	=	6500.0	nM	5.19
CHEMBL164660	PSORALEN	IC50	=	11000.0	nM	4.96
CHEMBL416	METHOXSALEN	IC50	=	28000.0	nM	4.55
CHEMBL164660	PSORALEN	Inhibition		-	%	-
CHEMBL416	METHOXSALEN	Inhibition		-	%	-
CHEMBL24171	BERGAPTEN	Inhibition		-	%	-