Assay Detail
Binding
CHEMBL1066212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant IKK2-mediated transfer of [gamma33P]ATP to biotinylated IkappaBalpha after 30 mins by scintillation counting
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.72 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610730 | — | — | 1 | 8.00 |
| CHEMBL589338 | — | — | 1 | 7.72 |
| CHEMBL592893 | — | — | 1 | 7.60 |
| CHEMBL600637 | — | — | 1 | 7.57 |
| CHEMBL591174 | — | — | 1 | 7.54 |
| CHEMBL601077 | — | — | 1 | 7.48 |
| CHEMBL590515 | — | — | 1 | 7.47 |
| CHEMBL590901 | — | — | 1 | 7.40 |
| CHEMBL591200 | — | — | 1 | 7.35 |
| CHEMBL590767 | — | — | 1 | 7.34 |
| CHEMBL601921 | — | — | 1 | 7.33 |
| CHEMBL601080 | — | — | 1 | 7.32 |
| CHEMBL601727 | — | — | 1 | 7.29 |
| CHEMBL601078 | — | — | 1 | 7.28 |
| CHEMBL591256 | — | — | 1 | 7.27 |
| CHEMBL601079 | — | — | 1 | 7.23 |
| CHEMBL589339 | — | — | 1 | 7.16 |
| CHEMBL591387 | — | — | 1 | 7.05 |
| CHEMBL590921 | — | — | 1 | 7.01 |
| CHEMBL590961 | — | — | 1 | 6.97 |
| CHEMBL591764 | — | — | 1 | 6.90 |
| CHEMBL603405 | — | — | 1 | 6.84 |
| CHEMBL589540 | — | — | 1 | 6.68 |
| CHEMBL590598 | — | — | 1 | 6.53 |
| CHEMBL592892 | — | — | 1 | 6.46 |
| CHEMBL591246 | — | — | 1 | 6.32 |
| CHEMBL592002 | — | — | 1 | 6.23 |
| CHEMBL590713 | — | — | 1 | 6.21 |
| CHEMBL602316 | — | — | 1 | 5.90 |
| CHEMBL590516 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610730 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL589338 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL592893 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL600637 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL591174 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL601077 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL590515 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL590901 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL591200 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL590767 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL601921 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL601080 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL601727 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL601078 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL591256 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL601079 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL589339 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL591387 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL590921 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL590961 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL591764 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL603405 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL589540 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL590598 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL592892 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL591246 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL592002 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL590713 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL602316 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL590516 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL590783 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL589569 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL600028 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL589808 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL591245 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL603140 | — | IC50 | = | 17300.0 | nM | 4.76 |