Assay Detail
Binding
CHEMBL1066254
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Inhibition of guinea pig liver transglutaminase
141
Total Activities
141
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein-glutamine gamma-glutamyltransferase (CHEMBL3308976) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Potent transglutaminase inhibitors, aryl beta-aminoethyl ketones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 141 | 5.56 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598522 | — | — | 1 | 7.09 |
| CHEMBL597916 | — | — | 1 | 7.00 |
| CHEMBL610215 | — | — | 1 | 6.92 |
| CHEMBL598521 | — | — | 1 | 6.72 |
| CHEMBL598529 | — | — | 1 | 6.68 |
| CHEMBL611979 | — | — | 1 | 6.64 |
| CHEMBL597079 | — | — | 1 | 6.50 |
| CHEMBL597103 | — | — | 1 | 6.50 |
| CHEMBL589994 | — | — | 1 | 6.44 |
| CHEMBL598319 | — | — | 1 | 6.38 |
| CHEMBL597917 | — | — | 1 | 6.38 |
| CHEMBL599534 | — | — | 1 | 6.36 |
| CHEMBL599729 | — | — | 1 | 6.33 |
| CHEMBL599107 | — | — | 1 | 6.28 |
| CHEMBL582295 | — | — | 1 | 6.26 |
| CHEMBL608737 | — | — | 1 | 6.24 |
| CHEMBL599555 | — | — | 1 | 6.23 |
| CHEMBL611978 | — | — | 1 | 6.21 |
| CHEMBL590246 | — | — | 1 | 6.19 |
| CHEMBL598910 | — | — | 1 | 6.17 |
| CHEMBL599350 | — | — | 1 | 6.17 |
| CHEMBL609903 | — | — | 1 | 6.16 |
| CHEMBL602665 | — | — | 1 | 6.11 |
| CHEMBL590249 | — | — | 1 | 6.10 |
| CHEMBL600082 | — | — | 1 | 6.08 |
| CHEMBL599730 | — | — | 1 | 6.08 |
| CHEMBL598051 | — | — | 1 | 6.08 |
| CHEMBL611080 | — | — | 1 | 6.07 |
| CHEMBL590493 | — | — | 1 | 6.04 |
| CHEMBL602862 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598522 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL597916 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL610215 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL598521 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL598529 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL611979 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL597103 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL597079 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL589994 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL597917 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL598319 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL599534 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL599729 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL599107 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL582295 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL608737 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL599555 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL611978 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL590246 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL599350 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL598910 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL609903 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL602665 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL590249 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL598051 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL600082 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL599730 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL611080 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL590493 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL602862 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL598239 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL608730 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL596661 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL598240 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL600659 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL601264 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL590731 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL609894 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL597178 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL598718 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL597511 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL597714 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL607563 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL599535 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL609631 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL597918 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL598084 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL598905 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL598114 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL598701 | — | IC50 | = | 1700.0 | nM | 5.77 |