Assay Detail
Functional
CHEMBL1066263
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Antioxidant activity in Sprague-Dawley rat liver assessed as inhibition of malonaldehyde
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.03 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592397 | — | — | 1 | 5.18 |
| CHEMBL578298 | — | — | 1 | 5.16 |
| CHEMBL592178 | — | — | 1 | 5.15 |
| CHEMBL592354 | — | — | 1 | 5.13 |
| CHEMBL592321 | — | — | 1 | 5.12 |
| CHEMBL592396 | — | — | 1 | 5.06 |
| CHEMBL592174 | — | — | 1 | 5.05 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592397 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL578298 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL592178 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL592354 | — | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL592321 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL592396 | — | IC50 | = | 8690.0 | nM | 5.06 |
| CHEMBL592174 | — | IC50 | = | 8850.0 | nM | 5.05 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 43890.0 | nM | 4.36 |