Assay Detail

CHEMBL1067190

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Functional

Antiproliferative activity against human MCF7 cells by soft agar growth assay

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Semi-synthetic aristolactams--inhibitors of CDK2 enzyme.

Hegde VR, Borges S, Pu H, Patel M, Gullo VP, Wu B, Kirschmeier P, Williams MJ, Madison V, Fischmann T, Chan TM.
Bioorg Med Chem Lett (2010) 20 : 1384 -1387
PubMed 20097066 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL603097	—	—	1	8.70
CHEMBL388956	ARISTOLACTAM AIIIA	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL603097	—	IC50	=	2.0	nM	8.70
CHEMBL388956	ARISTOLACTAM AIIIA	IC50	>	10.0	nM	-