Assay Detail
Binding
CHEMBL1067198
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Activity at human vasopressin V2 receptor expressed in CHO cells by NFAT-luciferase gene reporter assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Subtlety of the structure-affinity and structure-efficacy relationships around a nonpeptide oxytocin receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.51 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603708 | — | — | 1 | 8.12 |
| CHEMBL363910 | — | — | 1 | 7.40 |
| CHEMBL360648 | — | — | 1 | 6.07 |
| CHEMBL24781 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603708 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL363910 | — | EC50 | = | 39.9 | nM | 7.40 |
| CHEMBL360648 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL24781 | — | EC50 | = | 37000.0 | nM | 4.43 |