Assay Detail
Binding
CHEMBL1067226
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Inhibition of recombinant wild type HIV1 protease assessed as hydrolysis of fluorogenic substrate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new thienyl ring containing HIV-1 protease inhibitors: promising preliminary pharmacological evaluation against recombinant HIV-1 proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.46 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.40 |
| CHEMBL591934 | — | — | 1 | 9.22 |
| CHEMBL577443 | — | — | 1 | 8.92 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.72 |
| CHEMBL606392 | — | — | 1 | 8.54 |
| CHEMBL577638 | — | — | 1 | 8.22 |
| CHEMBL591933 | — | — | 1 | 7.82 |
| CHEMBL578278 | — | — | 1 | 7.68 |
| CHEMBL578874 | — | — | 1 | 5.82 |
| CHEMBL578053 | — | — | 1 | 5.40 |
| CHEMBL577017 | — | — | 1 | 5.30 |
| CHEMBL597982 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL591934 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL577443 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL606392 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL577638 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL591933 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL578278 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL578874 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL578053 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL577017 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL597982 | — | IC50 | = | 30000.0 | nM | 4.52 |