Assay Detail
Binding
CHEMBL1067293
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Inhibition of mTOR
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.33 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595256 | — | — | 1 | 9.54 |
| CHEMBL593157 | — | — | 1 | 9.47 |
| CHEMBL592917 | — | — | 1 | 9.36 |
| CHEMBL594431 | — | — | 1 | 9.35 |
| CHEMBL594549 | — | — | 1 | 9.22 |
| CHEMBL594793 | — | — | 1 | 9.17 |
| CHEMBL595053 | — | — | 1 | 9.15 |
| CHEMBL595287 | — | — | 1 | 9.15 |
| CHEMBL606131 | — | — | 1 | 9.05 |
| CHEMBL594244 | — | — | 1 | 9.00 |
| CHEMBL594571 | — | — | 1 | 8.90 |
| CHEMBL604167 | — | — | 1 | 8.85 |
| CHEMBL594173 | — | — | 1 | 8.43 |
| CHEMBL594606 | — | — | 1 | 8.33 |
| CHEMBL605915 | — | — | 1 | 7.96 |
| CHEMBL596426 | — | — | 1 | 7.80 |
| CHEMBL605529 | — | — | 1 | 7.70 |
| CHEMBL593186 | — | — | 1 | 7.66 |
| CHEMBL596430 | — | — | 1 | 7.58 |
| CHEMBL595288 | — | — | 1 | 7.50 |
| CHEMBL595743 | — | — | 1 | 7.46 |
| CHEMBL510164 | — | — | 1 | 7.31 |
| CHEMBL593156 | — | — | 1 | 7.24 |
| CHEMBL603212 | — | — | 1 | 7.24 |
| CHEMBL594844 | — | — | 1 | 7.21 |
| CHEMBL594350 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595256 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL593157 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL592917 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL594431 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL594549 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL594793 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL595053 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL595287 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL606131 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL594244 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL594571 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL604167 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL594173 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL594606 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL605915 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL596426 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL605529 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL593186 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL596430 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL595288 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL595743 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL510164 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL593156 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL603212 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL594844 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL594350 | — | IC50 | = | 100.0 | nM | 7.00 |