Assay Detail
Binding
CHEMBL1067317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cloned glutamate carboxypeptidase 2
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.11 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596351 | — | — | 1 | 9.12 |
| CHEMBL595408 | — | — | 1 | 8.28 |
| CHEMBL604257 | — | — | 1 | 8.28 |
| CHEMBL594123 | — | — | 1 | 7.96 |
| CHEMBL593324 | — | — | 1 | 7.79 |
| CHEMBL594262 | — | — | 1 | 7.79 |
| CHEMBL593097 | — | — | 1 | 7.64 |
| CHEMBL595441 | — | — | 1 | 7.62 |
| CHEMBL595184 | — | — | 1 | 7.28 |
| CHEMBL594019 | — | — | 1 | 7.07 |
| CHEMBL595669 | — | — | 1 | 7.01 |
| CHEMBL593331 | — | — | 1 | 6.98 |
| CHEMBL594715 | — | — | 1 | 6.88 |
| CHEMBL604488 | — | — | 1 | 6.59 |
| CHEMBL593079 | — | — | 1 | 6.54 |
| CHEMBL594267 | — | — | 1 | 6.50 |
| CHEMBL593155 | — | — | 1 | 6.50 |
| CHEMBL593090 | — | — | 1 | 6.10 |
| CHEMBL593091 | — | — | 1 | 6.10 |
| CHEMBL607543 | — | — | 1 | 5.88 |
| CHEMBL608106 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596351 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL595408 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL604257 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL594123 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL593324 | — | Ki | = | 16.1 | nM | 7.79 |
| CHEMBL594262 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL593097 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL595441 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL595184 | — | Ki | = | 52.3 | nM | 7.28 |
| CHEMBL594019 | — | Ki | = | 85.1 | nM | 7.07 |
| CHEMBL595669 | — | Ki | = | 97.2 | nM | 7.01 |
| CHEMBL593331 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL594715 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL604488 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL593079 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL594267 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL593155 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL593090 | — | Ki | = | 794.0 | nM | 6.10 |
| CHEMBL593091 | — | Ki | = | 795.0 | nM | 6.10 |
| CHEMBL607543 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL608106 | — | Ki | = | 3430.0 | nM | 5.46 |