Assay Detail
Functional
CHEMBL1067384
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Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.80 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593792 | — | — | 1 | 7.50 |
| CHEMBL607530 | — | — | 1 | 7.40 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.92 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.64 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.62 |
| CHEMBL455600 | — | — | 1 | 6.47 |
| CHEMBL593231 | — | — | 1 | 6.42 |
| CHEMBL594240 | — | — | 1 | 6.35 |
| CHEMBL367738 | — | — | 1 | 6.32 |
| CHEMBL594246 | — | — | 1 | 6.24 |
| CHEMBL593930 | — | — | 1 | 6.19 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.11 |
| CHEMBL408157 | — | — | 1 | 5.68 |
| CHEMBL596112 | — | — | 1 | 5.62 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.58 |
| CHEMBL593018 | — | — | 1 | 5.50 |
| CHEMBL593073 | — | — | 1 | 5.19 |
| CHEMBL594030 | — | — | 1 | 5.11 |
| CHEMBL593688 | — | — | 1 | 4.89 |
| CHEMBL608989 | — | — | 1 | 4.87 |
| CHEMBL593094 | — | — | 1 | 4.83 |
| CHEMBL595665 | — | — | 1 | 4.75 |
| CHEMBL593072 | — | — | 1 | 4.72 |
| CHEMBL609575 | — | — | 1 | 4.63 |
| CHEMBL593929 | — | — | 1 | 4.53 |
| CHEMBL594467 | — | — | 1 | - |
| CHEMBL594400 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593792 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL607530 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL455600 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL593231 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL594240 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL367738 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL594246 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL593930 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL408157 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL596112 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL593018 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL593073 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL594030 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL593688 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL608989 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL593094 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL595665 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL593072 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL609575 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL593929 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL594467 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL594400 | — | IC50 | > | 37000.0 | nM | - |