Assay Detail
Toxicity
CHEMBL1067386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine and pyrimethamine-resistant Plasmodium falciparum K1
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Cell Type | L6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.98 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.92 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.82 |
| CHEMBL593930 | — | — | 1 | 5.64 |
| CHEMBL594246 | — | — | 1 | 5.41 |
| CHEMBL609575 | — | — | 1 | 5.30 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.03 |
| CHEMBL593688 | — | — | 1 | 4.74 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 4.73 |
| CHEMBL594030 | — | — | 1 | 4.70 |
| CHEMBL593094 | — | — | 1 | 4.69 |
| CHEMBL593073 | — | — | 1 | 4.57 |
| CHEMBL607530 | — | — | 1 | 4.49 |
| CHEMBL593792 | — | — | 1 | 4.33 |
| CHEMBL593018 | — | — | 1 | 4.30 |
| CHEMBL408157 | — | — | 1 | - |
| CHEMBL593231 | — | — | 1 | - |
| CHEMBL367738 | — | — | 1 | - |
| CHEMBL594240 | — | — | 1 | - |
| CHEMBL596112 | — | — | 1 | - |
| CHEMBL595665 | — | — | 1 | - |
| CHEMBL593929 | — | — | 1 | - |
| CHEMBL593072 | — | — | 1 | - |
| CHEMBL608989 | — | — | 1 | - |
| CHEMBL455600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL593930 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL594246 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL609575 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL593688 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL594030 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL593094 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL593073 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL607530 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL593792 | — | IC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL593018 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL408157 | — | IC50 | = | 185800.0 | nM | - |
| CHEMBL593231 | — | IC50 | = | 348700.0 | nM | - |
| CHEMBL367738 | — | IC50 | = | 372500.0 | nM | - |
| CHEMBL594240 | — | IC50 | > | 1089000.0 | nM | - |
| CHEMBL596112 | — | IC50 | > | 120000.0 | nM | - |
| CHEMBL595665 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL593929 | — | IC50 | > | 23200.0 | nM | - |
| CHEMBL593072 | — | IC50 | > | 35000.0 | nM | - |
| CHEMBL608989 | — | IC50 | > | 51000.0 | nM | - |
| CHEMBL455600 | — | IC50 | > | 853000.0 | nM | - |