Assay Detail
Binding
CHEMBL1067451
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Inhibition of Clostridium botulinum toxin BoNT/A light chain by HPLC-based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.69 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597791 | — | — | 1 | 5.36 |
| CHEMBL167448 | — | — | 1 | 5.03 |
| CHEMBL3216444 | — | — | 1 | 4.77 |
| CHEMBL598001 | — | — | 1 | 4.60 |
| CHEMBL597599 | — | — | 1 | 4.39 |
| CHEMBL597792 | — | — | 1 | 4.37 |
| CHEMBL598002 | — | — | 1 | 4.28 |
| CHEMBL603251 | — | — | 1 | - |
| CHEMBL598622 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597791 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL167448 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3216444 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL598001 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL597599 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL597792 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL598002 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL603251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL598622 | — | IC50 | > | 100000.0 | nM | - |