Assay Detail
Functional
CHEMBL1067692
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Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | 1321-N1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.37 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435402 | — | — | 1 | 8.60 |
| CHEMBL591905 | — | — | 1 | 7.96 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 7.85 |
| CHEMBL590527 | — | — | 1 | 7.10 |
| CHEMBL591433 | — | — | 1 | 6.38 |
| CHEMBL591434 | — | — | 1 | 6.34 |
| CHEMBL591435 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435402 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL591905 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL590527 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL591433 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL591434 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL591435 | — | EC50 | - | — | - |