Assay Detail
Binding
CHEMBL1067951
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Displacement of radiolabeled 1-alpha,25-(OH)2D3 from rat recombinant full length VDR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D(3) (2MD) selectively eliminates bone calcium mobilization activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.10 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL596532 | — | — | 1 | 10.70 |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 10.00 |
| CHEMBL594078 | — | — | 1 | 10.00 |
| CHEMBL607373 | — | — | 1 | 9.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL596532 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL846 | CALCITRIOL | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL594078 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL607373 | — | Ki | = | 0.2 | nM | 9.70 |