Assay Detail
Binding
CHEMBL1068004
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Inhibition of human rhodamine-labelled soluble CD69 by standard plate inhibition assay
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carboxylated calixarenes bind strongly to CD69 and protect CD69(+) killer cells from suicidal cell death induced by tumor cell surface ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.88 | 9.30 |
| pIC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601098 | — | — | 1 | 9.30 |
| CHEMBL591694 | — | — | 1 | 7.90 |
| CHEMBL601099 | — | — | 1 | 7.60 |
| CHEMBL601100 | — | — | 1 | 7.30 |
| CHEMBL591636 | — | — | 1 | 7.20 |
| CHEMBL596977 | — | — | 1 | 7.10 |
| CHEMBL601309 | — | — | 1 | 4.50 |
| CHEMBL591695 | — | — | 1 | 4.10 |
| CHEMBL601101 | — | — | 1 | - |
| CHEMBL601306 | — | — | 1 | - |
| CHEMBL601307 | — | — | 1 | - |
| CHEMBL601308 | — | — | 1 | - |
| CHEMBL447878 | N-ACETYLGLUCOSAMINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601098 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL591694 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL601099 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL601100 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL591636 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL596977 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL601309 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL591695 | — | IC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL601101 | — | IC50 | = | 398107.17 | nM | - |
| CHEMBL601306 | — | IC50 | = | 251188.64 | nM | - |
| CHEMBL601307 | — | pIC50 | - | — | - | |
| CHEMBL601308 | — | pIC50 | - | — | - | |
| CHEMBL447878 | N-ACETYLGLUCOSAMINE | IC50 | = | 1000000.0 | nM | - |