Assay Detail
Binding
CHEMBL1068007
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Inhibition of SiaTnTRI2-induced activation of CD69 high in human lymphocytes assessed as InsP2 production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carboxylated calixarenes bind strongly to CD69 and protect CD69(+) killer cells from suicidal cell death induced by tumor cell surface ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.49 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL591694 | — | — | 1 | 9.19 |
| CHEMBL601099 | — | — | 1 | 8.43 |
| CHEMBL601100 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL591694 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL601099 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL601100 | — | IC50 | = | 14.0 | nM | 7.85 |