Assay Detail
Binding
CHEMBL1068052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from human cloned NET expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of fluorinated diphenyloxide derivatives and sulfur analogs as serotonin transporter ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.99 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL589179 | — | — | 1 | 6.39 |
| CHEMBL592697 | — | — | 1 | 6.30 |
| CHEMBL589178 | — | — | 1 | 6.20 |
| CHEMBL591514 | — | — | 1 | 6.18 |
| CHEMBL592696 | — | — | 1 | 5.92 |
| CHEMBL246388 | — | — | 1 | 5.91 |
| CHEMBL589086 | — | — | 1 | 5.05 |
| CHEMBL589177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL589179 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL592697 | — | Ki | = | 503.0 | nM | 6.30 |
| CHEMBL589178 | — | Ki | = | 632.0 | nM | 6.20 |
| CHEMBL591514 | — | Ki | = | 667.0 | nM | 6.18 |
| CHEMBL592696 | — | Ki | = | 1203.0 | nM | 5.92 |
| CHEMBL246388 | — | Ki | = | 1245.0 | nM | 5.91 |
| CHEMBL589086 | — | Ki | = | 8854.0 | nM | 5.05 |
| CHEMBL589177 | — | Ki | > | 500.0 | nM | - |