Assay Detail
Binding
CHEMBL1068124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3HDTBZ from VMAT2 in rat whole brain vesicles by liquid scintillation spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Synaptic vesicular amine transporter (CHEMBL4828) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.45 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603692 | — | — | 1 | 5.70 |
| CHEMBL599268 | — | — | 1 | 5.68 |
| CHEMBL599267 | — | — | 1 | 5.61 |
| CHEMBL597298 | — | — | 1 | 5.52 |
| CHEMBL597297 | — | — | 1 | 5.49 |
| CHEMBL596683 | — | — | 1 | 5.46 |
| CHEMBL604306 | — | — | 1 | 5.40 |
| CHEMBL605420 | — | — | 1 | 5.38 |
| CHEMBL605748 | — | — | 1 | 5.37 |
| CHEMBL597299 | — | — | 1 | 5.37 |
| CHEMBL597085 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603692 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL599268 | — | Ki | = | 2090.0 | nM | 5.68 |
| CHEMBL599267 | — | Ki | = | 2480.0 | nM | 5.61 |
| CHEMBL597298 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL597297 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL596683 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL604306 | — | Ki | = | 3980.0 | nM | 5.40 |
| CHEMBL605420 | — | Ki | = | 4120.0 | nM | 5.38 |
| CHEMBL605748 | — | Ki | = | 4230.0 | nM | 5.37 |
| CHEMBL597299 | — | Ki | = | 4230.0 | nM | 5.37 |
| CHEMBL597085 | — | Ki | = | 10800.0 | nM | 4.97 |