Assay Detail
Functional
CHEMBL1068151
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Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-4A5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.75 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3542340 | ISOSILYBIN B | — | 1 | 5.21 |
| CHEMBL592676 | ISOSILYBIN A | — | 1 | 5.00 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.85 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.82 |
| CHEMBL253335 | — | — | 1 | 4.82 |
| CHEMBL9167 | ANASTATIN A | — | 1 | 4.80 |
| CHEMBL406378 | — | — | 1 | 4.80 |
| CHEMBL222021 | PROTOCATECHUALDEHYDE | — | 1 | 4.77 |
| CHEMBL431701 | SILYBIN A | 3.0 | 1 | 4.68 |
| CHEMBL591728 | — | — | 1 | 4.68 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.60 |
| CHEMBL591727 | HIEROCHIN A | — | 1 | 4.60 |
| CHEMBL591231 | — | — | 1 | 4.54 |
| CHEMBL2368657 | Hierochin B | — | 1 | 4.52 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 4.50 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3542340 | ISOSILYBIN B | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL592676 | ISOSILYBIN A | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL253335 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL9167 | ANASTATIN A | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL406378 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL222021 | PROTOCATECHUALDEHYDE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL431701 | SILYBIN A | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL591728 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL591727 | HIEROCHIN A | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL591231 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2368657 | Hierochin B | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL8996 | ERIODICTYOL | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 174000.0 | nM | - |