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Assay Detail

CHEMBL1068293

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Functional
Antiviral activity against human influenza A virus A/WSN/33 (H1N1) in MDCK cells assessed as reduction of virus-induced cytopathic effect
ChEMBL ↗
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Influenza A virus
Cell Type MDCK
Confidence 1 — Organism
Curated By Autocuration

Target

Influenza A virus (CHEMBL613740) ↗
Type ORGANISM
Organism Influenza A virus

Publication

Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.
Yeh JY, Coumar MS, Horng JT, Shiao HY, Kuo FM, Lee HL, Chen IC, Chang CW, Tang WF, Tseng SN, Chen CJ, Shih SR, Hsu JT, Liao CC, Chao YS, Hsieh HP.
J Med Chem (2010) 53 : 1519 -1533
PubMed 20092255 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 66 6.18 7.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL603919 — — 1 7.22
CHEMBL222813 ZANAMIVIR 4.0 1 7.22
CHEMBL602496 — — 1 7.16
CHEMBL601648 — — 1 7.10
CHEMBL601655 — — 1 7.10
CHEMBL597507 — — 1 7.05
CHEMBL604332 — — 1 7.00
CHEMBL600812 — — 1 7.00
CHEMBL600808 — — 1 6.96
CHEMBL601230 — — 1 6.92
CHEMBL601656 — — 1 6.85
CHEMBL600995 — — 1 6.85
CHEMBL602497 — — 1 6.82
CHEMBL601654 — — 1 6.82
CHEMBL591218 — — 1 6.82
CHEMBL604750 — — 1 6.62
CHEMBL600813 — — 1 6.60
CHEMBL601676 — — 1 6.58
CHEMBL602270 — — 1 6.58
CHEMBL608087 — — 1 6.54
CHEMBL601846 — — 1 6.54
CHEMBL605586 — — 1 6.54
CHEMBL605989 — — 1 6.50
CHEMBL611509 — — 1 6.39
CHEMBL605369 — — 1 6.34
CHEMBL601444 — — 1 6.33
CHEMBL605794 — — 1 6.28
CHEMBL603709 — — 1 6.21
CHEMBL604327 — — 1 6.20
CHEMBL602879 — — 1 6.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL603919 — IC50 = 60.0 nM 7.22
CHEMBL222813 ZANAMIVIR IC50 = 60.0 nM 7.22
CHEMBL602496 — IC50 = 70.0 nM 7.16
CHEMBL601648 — IC50 = 80.0 nM 7.10
CHEMBL601655 — IC50 = 80.0 nM 7.10
CHEMBL597507 — IC50 = 90.0 nM 7.05
CHEMBL604332 — IC50 = 100.0 nM 7.00
CHEMBL600812 — IC50 = 100.0 nM 7.00
CHEMBL600808 — IC50 = 110.0 nM 6.96
CHEMBL601230 — IC50 = 120.0 nM 6.92
CHEMBL601656 — IC50 = 140.0 nM 6.85
CHEMBL600995 — IC50 = 140.0 nM 6.85
CHEMBL591218 — IC50 = 150.0 nM 6.82
CHEMBL601654 — IC50 = 150.0 nM 6.82
CHEMBL602497 — IC50 = 150.0 nM 6.82
CHEMBL604750 — IC50 = 240.0 nM 6.62
CHEMBL600813 — IC50 = 250.0 nM 6.60
CHEMBL601676 — IC50 = 260.0 nM 6.58
CHEMBL602270 — IC50 = 260.0 nM 6.58
CHEMBL608087 — IC50 = 290.0 nM 6.54
CHEMBL601846 — IC50 = 290.0 nM 6.54
CHEMBL605586 — IC50 = 290.0 nM 6.54
CHEMBL605989 — IC50 = 320.0 nM 6.50
CHEMBL611509 — IC50 = 410.0 nM 6.39
CHEMBL605369 — IC50 = 460.0 nM 6.34
CHEMBL601444 — IC50 = 470.0 nM 6.33
CHEMBL605794 — IC50 = 530.0 nM 6.28
CHEMBL603709 — IC50 = 610.0 nM 6.21
CHEMBL604327 — IC50 = 630.0 nM 6.20
CHEMBL602879 — IC50 = 640.0 nM 6.19
CHEMBL601847 — IC50 = 650.0 nM 6.19
CHEMBL600601 — IC50 = 650.0 nM 6.19
CHEMBL600824 — IC50 = 720.0 nM 6.14
CHEMBL602271 — IC50 = 720.0 nM 6.14
CHEMBL601649 — IC50 = 730.0 nM 6.14
CHEMBL603908 — IC50 = 760.0 nM 6.12
CHEMBL606417 — IC50 = 820.0 nM 6.09
CHEMBL602498 — IC50 = 870.0 nM 6.06
CHEMBL604745 — IC50 = 880.0 nM 6.06
CHEMBL603087 — IC50 = 1410.0 nM 5.85
CHEMBL605157 — IC50 = 1670.0 nM 5.78
CHEMBL605587 — IC50 = 1710.0 nM 5.77
CHEMBL600389 — IC50 = 1910.0 nM 5.72
CHEMBL601845 — IC50 = 2430.0 nM 5.61
CHEMBL603236 — IC50 = 2650.0 nM 5.58
CHEMBL601236 — IC50 = 2790.0 nM 5.55
CHEMBL604338 — IC50 = 3920.0 nM 5.41
CHEMBL599886 — IC50 = 4510.0 nM 5.35
CHEMBL599765 — IC50 = 5280.0 nM 5.28
CHEMBL597506 — IC50 = 6090.0 nM 5.21