Assay Detail
Functional
CHEMBL1068424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.69 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | 3.0 | 1 | 10.72 |
| CHEMBL594016 | — | — | 1 | 9.82 |
| CHEMBL594649 | — | — | 1 | 9.19 |
| CHEMBL594895 | — | — | 1 | 9.01 |
| CHEMBL593623 | — | — | 1 | 7.86 |
| CHEMBL594862 | — | — | 1 | 7.76 |
| CHEMBL595046 | — | — | 1 | 7.72 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 7.40 |
| CHEMBL595262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17976 | RESINIFERATOXIN | EC50 | = | 0.019 | nM | 10.72 |
| CHEMBL594016 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL594649 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL594895 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL593623 | — | EC50 | = | 13.7 | nM | 7.86 |
| CHEMBL594862 | — | EC50 | = | 17.4 | nM | 7.76 |
| CHEMBL595046 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL595262 | — | EC50 | = | 0.0047 | nM | - |