Assay Detail
Binding
CHEMBL1068447
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Selectivity, ratio of Ki for sigma 1 to Ki for sigma 2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxo-bridged isomers of aza-trishomocubane sigma (sigma) receptor ligands: Synthesis, in vitro binding, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.04 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602850 | — | — | 1 | 9.60 |
| CHEMBL590615 | — | — | 1 | 9.39 |
| CHEMBL600053 | — | — | 1 | 8.86 |
| CHEMBL608560 | — | — | 1 | 8.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602850 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL590615 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL600053 | — | Ki | = | 1.39 | nM | 8.86 |
| CHEMBL608560 | — | Ki | = | 4.94 | nM | 8.31 |