Assay Detail
Binding
CHEMBL1068541
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Inhibition of bovine retina PDE6
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (CHEMBL3741) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.20 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594160 | — | — | 1 | 6.85 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.85 |
| CHEMBL604271 | — | — | 1 | 6.50 |
| CHEMBL595104 | — | — | 1 | 6.47 |
| CHEMBL521075 | — | — | 1 | 6.34 |
| CHEMBL596489 | — | — | 1 | 6.22 |
| CHEMBL603422 | — | — | 1 | 6.15 |
| CHEMBL592986 | — | — | 1 | 5.96 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 5.52 |
| CHEMBL593225 | — | — | 1 | 5.10 |
| CHEMBL595330 | — | — | 1 | - |
| CHEMBL596454 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594160 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL604271 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL595104 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL521075 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL596489 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL603422 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL592986 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL779 | TADALAFIL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL593225 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL595330 | — | IC50 | - | — | - | |
| CHEMBL596454 | — | IC50 | - | — | - |