Assay Detail
Binding
CHEMBL1068543
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine platelet PDE5
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL3478) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Discovery of potent, selective, and orally bioavailable PDE5 inhibitor: Methyl-4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-ylmethylcarbamate (CKD 533).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.49 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594160 | — | — | 1 | 9.22 |
| CHEMBL521075 | — | — | 1 | 9.00 |
| CHEMBL604271 | — | — | 1 | 9.00 |
| CHEMBL595330 | — | — | 1 | 9.00 |
| CHEMBL595104 | — | — | 1 | 9.00 |
| CHEMBL592986 | — | — | 1 | 8.52 |
| CHEMBL603422 | — | — | 1 | 8.52 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.00 |
| CHEMBL596454 | — | — | 1 | 7.96 |
| CHEMBL593225 | — | — | 1 | 7.92 |
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 7.92 |
| CHEMBL596489 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594160 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL521075 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL604271 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL595330 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL595104 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL592986 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL603422 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL596454 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL593225 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL779 | TADALAFIL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL596489 | — | IC50 | = | 17.0 | nM | 7.77 |