Assay Detail
Functional
CHEMBL1068599
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Antimalarial activity against Plasmodium falciparum Dd2 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation by microbeta liquid scintillation counter
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity of azadipeptide nitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.16 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594719 | — | — | 1 | 5.68 |
| CHEMBL604079 | — | — | 1 | 5.44 |
| CHEMBL604078 | — | — | 1 | 5.12 |
| CHEMBL604281 | — | — | 1 | 4.82 |
| CHEMBL608115 | — | — | 1 | 4.75 |
| CHEMBL595637 | — | — | 1 | - |
| CHEMBL603537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594719 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL604079 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL604078 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL604281 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL608115 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL595637 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL603537 | — | IC50 | > | 25000.0 | nM | - |