Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1068629

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Bacillus anthracis sortase A by FRET assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.
Suree N, Yi SW, Thieu W, Marohn M, Damoiseaux R, Chan A, Jung ME, Clubb RT.
Bioorg Med Chem (2009) 17 : 7174 -7185
PubMed 19781950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.37 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL593305 1 6.52
CHEMBL595865 1 6.05
CHEMBL609892 1 5.92
CHEMBL593687 1 5.92
CHEMBL593330 1 5.85
CHEMBL596334 1 5.85
CHEMBL594473 1 5.85
CHEMBL608136 1 5.77
CHEMBL602589 1 5.75
CHEMBL596541 1 5.75
CHEMBL595437 1 5.28
CHEMBL596102 1 5.17
CHEMBL608988 1 4.89
CHEMBL596542 1 4.85
CHEMBL609271 1 4.85
CHEMBL596322 1 4.70
CHEMBL243293 1 4.57
CHEMBL610481 1 4.28
CHEMBL593084 1 4.13
CHEMBL593085 1 -
CHEMBL595623 1 -
CHEMBL595640 1 -
CHEMBL610744 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL593305 IC50 = 300.0 nM 6.52
CHEMBL595865 IC50 = 900.0 nM 6.05
CHEMBL609892 IC50 = 1200.0 nM 5.92
CHEMBL593687 IC50 = 1200.0 nM 5.92
CHEMBL593330 IC50 = 1400.0 nM 5.85
CHEMBL596334 IC50 = 1400.0 nM 5.85
CHEMBL594473 IC50 = 1400.0 nM 5.85
CHEMBL608136 IC50 = 1700.0 nM 5.77
CHEMBL602589 IC50 = 1800.0 nM 5.75
CHEMBL596541 IC50 = 1800.0 nM 5.75
CHEMBL595437 IC50 = 5200.0 nM 5.28
CHEMBL596102 IC50 = 6700.0 nM 5.17
CHEMBL608988 IC50 = 13000.0 nM 4.89
CHEMBL596542 IC50 = 14000.0 nM 4.85
CHEMBL609271 IC50 = 14000.0 nM 4.85
CHEMBL596322 IC50 = 20000.0 nM 4.70
CHEMBL243293 IC50 = 27000.0 nM 4.57
CHEMBL610481 IC50 = 53000.0 nM 4.28
CHEMBL593084 IC50 = 74000.0 nM 4.13
CHEMBL593085 IC50 = 247000.0 nM -
CHEMBL595623 IC50 > 50000.0 nM -
CHEMBL595640 IC50 > 50000.0 nM -
CHEMBL610744 IC50 > 50000.0 nM -