Assay Detail
Binding
CHEMBL1068909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]noradrenalin reuptake at human NET expressed in LLCPK cells by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | LLCPK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.60 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608151 | — | — | 1 | 9.80 |
| CHEMBL597000 | — | — | 1 | 9.60 |
| CHEMBL2021580 | — | — | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608151 | — | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL597000 | — | IC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL2021580 | — | IC50 | = | 0.3981 | nM | 9.40 |