Assay Detail
Binding
CHEMBL1068958
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Inhibition of human recombinant MAOA assessed as 4-hydroxyquinoline formation by fluorimetry
14
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.46 | 7.17 |
| Ki | 7 | 6.94 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602464 | — | — | 2 | 7.64 |
| CHEMBL602260 | — | — | 2 | 7.44 |
| CHEMBL602466 | — | — | 2 | 7.29 |
| CHEMBL602465 | — | — | 2 | 6.75 |
| CHEMBL589765 | — | — | 2 | 6.75 |
| CHEMBL602880 | — | — | 2 | 6.47 |
| CHEMBL602259 | — | — | 2 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602464 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL602260 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL602466 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL602464 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL602260 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL602466 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL602465 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL589765 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL602880 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL602465 | — | IC50 | = | 542.0 | nM | 6.27 |
| CHEMBL589765 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL602259 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL602880 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL602259 | — | IC50 | = | 1770.0 | nM | 5.75 |