Assay Detail
Functional
CHEMBL1068976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.54 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602468 | — | — | 1 | 9.10 |
| CHEMBL606422 | — | — | 1 | 9.00 |
| CHEMBL601222 | — | — | 1 | 8.70 |
| CHEMBL590983 | — | — | 1 | 8.52 |
| CHEMBL434063 | — | — | 1 | 8.22 |
| CHEMBL602263 | — | — | 1 | 7.77 |
| CHEMBL602670 | — | — | 1 | 7.66 |
| CHEMBL602469 | — | — | 1 | 7.33 |
| CHEMBL606425 | — | — | 1 | 6.79 |
| CHEMBL590984 | — | — | 1 | 6.70 |
| CHEMBL601861 | — | — | 1 | 6.47 |
| CHEMBL601678 | — | — | 1 | 6.05 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602468 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL606422 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL601222 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL590983 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL434063 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL602263 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL602670 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL602469 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL606425 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL590984 | — | EC50 | = | 201.0 | nM | 6.70 |
| CHEMBL601861 | — | EC50 | = | 338.0 | nM | 6.47 |
| CHEMBL601678 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1017 | TELMISARTAN | EC50 | = | 2020.0 | nM | 5.70 |