Assay Detail
Binding
CHEMBL1068982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled GW-2433 from human PPARalpha ligand binding domain expressed in Escherichia coli
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.15 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL602263 | — | — | 1 | 5.15 |
| CHEMBL590984 | — | — | 1 | - |
| CHEMBL590983 | — | — | 1 | - |
| CHEMBL601222 | — | — | 1 | - |
| CHEMBL601861 | — | — | 1 | - |
| CHEMBL606422 | — | — | 1 | - |
| CHEMBL602670 | — | — | 1 | - |
| CHEMBL602469 | — | — | 1 | - |
| CHEMBL602468 | — | — | 1 | - |
| CHEMBL606425 | — | — | 1 | - |
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | - |
| CHEMBL601678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL602263 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL590984 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL590983 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL601222 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL601861 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL606422 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL602670 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL602469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL602468 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL606425 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1017 | TELMISARTAN | IC50 | > | 10000.0 | nM | - |
| CHEMBL601678 | — | IC50 | - | — | - |