Assay Detail
Binding
CHEMBL1069162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of MAOA in rat liver homogenate by spectrophotometrically
24
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.08 | 6.16 |
| Ki | 12 | 6.25 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594029 | — | — | 2 | 8.38 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 2 | 8.26 |
| CHEMBL593341 | — | — | 2 | 7.41 |
| CHEMBL607513 | — | — | 2 | 6.19 |
| CHEMBL596228 | — | — | 2 | 6.06 |
| CHEMBL596340 | — | — | 2 | 5.76 |
| CHEMBL592976 | — | — | 2 | 5.52 |
| CHEMBL596453 | — | — | 2 | 5.41 |
| CHEMBL596313 | — | — | 2 | 5.37 |
| CHEMBL596339 | — | — | 2 | 5.30 |
| CHEMBL607552 | — | — | 2 | 5.05 |
| CHEMBL972 | SELEGILINE | 4.0 | 2 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594029 | — | Ki | = | 4.22 | nM | 8.38 |
| CHEMBL86304 | MOCLOBEMIDE | Ki | = | 5.53 | nM | 8.26 |
| CHEMBL593341 | — | Ki | = | 39.15 | nM | 7.41 |
| CHEMBL607513 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL593341 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL594029 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL596228 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL596340 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL607513 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL596228 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL596340 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL592976 | — | Ki | = | 2990.0 | nM | 5.52 |
| CHEMBL596453 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL596313 | — | Ki | = | 4260.0 | nM | 5.37 |
| CHEMBL596339 | — | Ki | = | 5010.0 | nM | 5.30 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL607552 | — | Ki | = | 8820.0 | nM | 5.05 |
| CHEMBL596339 | — | IC50 | = | 62340.0 | nM | 4.21 |
| CHEMBL596453 | — | IC50 | = | 80220.0 | nM | 4.10 |
| CHEMBL972 | SELEGILINE | IC50 | = | 90550.0 | nM | 4.04 |
| CHEMBL592976 | — | IC50 | = | 95200.0 | nM | 4.02 |
| CHEMBL596313 | — | IC50 | = | 110450.0 | nM | - |
| CHEMBL972 | SELEGILINE | Ki | = | 105660.0 | nM | - |
| CHEMBL607552 | — | IC50 | = | 108340.0 | nM | - |