Assay Detail
Binding
CHEMBL1069214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of NBD-Toc from human recombinant alphaTTP
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-tocopherol transfer protein (CHEMBL3308919) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interaction studies between human alpha-tocopherol transfer protein and nitric oxide donor tocopherol analogues with LDL-protective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.42 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247483 | — | — | 1 | 6.44 |
| CHEMBL595636 | — | — | 1 | 5.95 |
| CHEMBL391747 | — | — | 1 | 5.66 |
| CHEMBL47 | ALPHA-TOCOPHEROL | — | 1 | 5.62 |
| CHEMBL594042 | — | — | 1 | 5.62 |
| CHEMBL391748 | — | — | 1 | 4.40 |
| CHEMBL248495 | — | — | 1 | 4.22 |
| CHEMBL247276 | — | — | 1 | - |
| CHEMBL593785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247483 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL595636 | — | Kd | = | 1130.0 | nM | 5.95 |
| CHEMBL391747 | — | Kd | = | 2190.0 | nM | 5.66 |
| CHEMBL47 | ALPHA-TOCOPHEROL | Kd | = | 2420.0 | nM | 5.62 |
| CHEMBL594042 | — | Kd | = | 2390.0 | nM | 5.62 |
| CHEMBL391748 | — | Kd | = | 40000.0 | nM | 4.40 |
| CHEMBL248495 | — | Kd | = | 60000.0 | nM | 4.22 |
| CHEMBL247276 | — | Kd | = | 165000.0 | nM | - |
| CHEMBL593785 | — | Kd | = | 108000.0 | nM | - |