Assay Detail
Binding
CHEMBL1069455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT1 by Flour de Lys assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.69 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597477 | — | — | 1 | 6.80 |
| CHEMBL611665 | — | — | 1 | 5.28 |
| CHEMBL596657 | — | — | 1 | 5.08 |
| CHEMBL596656 | — | — | 1 | 4.39 |
| CHEMBL597845 | SALERMIDE | — | 1 | 4.37 |
| CHEMBL596655 | — | — | 1 | 4.36 |
| CHEMBL372375 | — | — | 1 | 4.32 |
| CHEMBL200762 | — | — | 1 | 4.23 |
| CHEMBL490905 | — | — | 1 | 4.05 |
| CHEMBL86537 | SPLITOMICIN | — | 1 | 4.02 |
| CHEMBL380797 | SIRTINOL | — | 1 | - |
| CHEMBL224864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597477 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL611665 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL596657 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL596656 | — | IC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL597845 | SALERMIDE | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL596655 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL372375 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL200762 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL490905 | — | IC50 | = | 89800.0 | nM | 4.05 |
| CHEMBL86537 | SPLITOMICIN | IC50 | = | 96200.0 | nM | 4.02 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 123300.0 | nM | - |
| CHEMBL224864 | — | IC50 | > | 50000.0 | nM | - |