Assay Detail
Binding
CHEMBL1069561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of yeast alpha-glucosidase MAL12 assessed as inhibition of p-nitrophenol release by spectrophotometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Alpha-glucosidase MAL12 (CHEMBL2932) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Synthesis, biological activity, and molecular modeling studies of 1H-1,2,3-triazole derivatives of carbohydrates as alpha-glucosidases inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.03 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL598823 | — | — | 1 | 5.42 |
| CHEMBL597186 | — | — | 1 | 5.28 |
| CHEMBL597996 | — | — | 1 | 5.24 |
| CHEMBL598822 | — | — | 1 | 4.83 |
| CHEMBL603160 | — | — | 1 | 4.82 |
| CHEMBL590279 | — | — | 1 | 4.61 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL598823 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL597186 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL597996 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL598822 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL603160 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL590279 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 108800.0 | nM | - |