Assay Detail
Binding
CHEMBL1069650
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Inhibition of human 15PGDH expressed in Escherichia coli BL-21 by fluorescence spectrophotometry
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (CHEMBL1293255) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.40 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590265 | — | — | 1 | 7.51 |
| CHEMBL84603 | — | — | 1 | 7.35 |
| CHEMBL599406 | — | — | 1 | 7.29 |
| CHEMBL599018 | — | — | 1 | 7.28 |
| CHEMBL610221 | — | — | 1 | 7.22 |
| CHEMBL598397 | — | — | 1 | 6.94 |
| CHEMBL591466 | — | — | 1 | 6.91 |
| CHEMBL598880 | — | — | 1 | 6.76 |
| CHEMBL599019 | — | — | 1 | 6.66 |
| CHEMBL597576 | — | — | 1 | 6.63 |
| CHEMBL607870 | — | — | 1 | 6.60 |
| CHEMBL599407 | — | — | 1 | 6.56 |
| CHEMBL598182 | — | — | 1 | 6.54 |
| CHEMBL598183 | — | — | 1 | 6.37 |
| CHEMBL608142 | — | — | 1 | 6.28 |
| CHEMBL598787 | — | — | 1 | 6.28 |
| CHEMBL599220 | — | — | 1 | 6.21 |
| CHEMBL590988 | — | — | 1 | 6.20 |
| CHEMBL599004 | — | — | 1 | 6.18 |
| CHEMBL599002 | — | — | 1 | 6.15 |
| CHEMBL598175 | — | — | 1 | 6.12 |
| CHEMBL599395 | — | — | 1 | 6.09 |
| CHEMBL606032 | — | — | 1 | 6.06 |
| CHEMBL601089 | — | — | 1 | 6.05 |
| CHEMBL599003 | — | — | 1 | 5.90 |
| CHEMBL599416 | — | — | 1 | 5.84 |
| CHEMBL599417 | — | — | 1 | 5.71 |
| CHEMBL597377 | — | — | 1 | 5.59 |
| CHEMBL590503 | — | — | 1 | 5.43 |
| CHEMBL608443 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590265 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL84603 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL599406 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL599018 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL610221 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL598397 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL591466 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL598880 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL599019 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL597576 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL607870 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL599407 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL598182 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL598183 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL608142 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL598787 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL599220 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL590988 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL599004 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL599002 | — | IC50 | = | 713.0 | nM | 6.15 |
| CHEMBL598175 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL599395 | — | IC50 | = | 814.0 | nM | 6.09 |
| CHEMBL606032 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL601089 | — | IC50 | = | 893.0 | nM | 6.05 |
| CHEMBL599003 | — | IC50 | = | 1248.0 | nM | 5.90 |
| CHEMBL599416 | — | IC50 | = | 1442.0 | nM | 5.84 |
| CHEMBL599417 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL597377 | — | IC50 | = | 2585.0 | nM | 5.59 |
| CHEMBL590503 | — | IC50 | = | 3719.0 | nM | 5.43 |
| CHEMBL608443 | — | IC50 | = | 3789.0 | nM | 5.42 |
| CHEMBL599600 | — | IC50 | - | — | - |