Assay Detail
Binding
CHEMBL1069850
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Inhibition of Clostridium botulinum BoNT/A
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.51 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237776 | — | — | 1 | 6.10 |
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | — | 1 | 6.05 |
| CHEMBL593815 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237776 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL237370 | CINNAMIC ACID HYDROXAMATE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL593815 | — | IC50 | = | 41000.0 | nM | 4.39 |