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Assay Detail

CHEMBL1069867

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Binding
Inhibition of COX2 assessed as PGF2alpha level by EIA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.
Moon JT, Jeon JY, Park HA, Noh YS, Lee KT, Kim J, Choo DJ, Lee JY.
Bioorg Med Chem Lett (2010) 20 : 734 -737
PubMed 20004572 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.94 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL42485 DUP-697 1 6.77
CHEMBL595838 1 4.81
CHEMBL595596 1 4.79
CHEMBL603439 1 4.79
CHEMBL593268 1 4.78
CHEMBL610196 1 4.76
CHEMBL603856 1 4.76
CHEMBL603434 1 4.73
CHEMBL609572 1 4.73
CHEMBL595852 1 4.70
CHEMBL595153 1 4.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL42485 DUP-697 IC50 = 170.0 nM 6.77
CHEMBL595838 IC50 = 15620.0 nM 4.81
CHEMBL595596 IC50 = 16040.0 nM 4.79
CHEMBL603439 IC50 = 16340.0 nM 4.79
CHEMBL593268 IC50 = 16630.0 nM 4.78
CHEMBL610196 IC50 = 17510.0 nM 4.76
CHEMBL603856 IC50 = 17500.0 nM 4.76
CHEMBL603434 IC50 = 18520.0 nM 4.73
CHEMBL609572 IC50 = 18450.0 nM 4.73
CHEMBL595852 IC50 = 20110.0 nM 4.70
CHEMBL595153 IC50 = 21010.0 nM 4.68