Assay Detail
Binding
CHEMBL1070085
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Inhibition of reduced carboxymethylated kappa-casein fibril formation measured every 5 mins after 1000 mins by thioflavin T staining-based binding assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carboxymethylated-kappa-casein: a convenient tool for the identification of polyphenolic inhibitors of amyloid fibril formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.75 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.43 |
| CHEMBL19074 | PENTAACETYLQUERCETIN | — | 1 | 5.17 |
| CHEMBL164 | MYRICETIN | — | 1 | 5.07 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.87 |
| CHEMBL170405 | ROBINETIN | — | 1 | 4.86 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.48 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 4.40 |
| CHEMBL28626 | MORIN | — | 1 | 4.30 |
| CHEMBL309490 | GALANGIN | — | 1 | 4.21 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL19074 | PENTAACETYLQUERCETIN | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL164 | MYRICETIN | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL50 | QUERCETIN | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL170405 | ROBINETIN | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL28626 | MORIN | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL309490 | GALANGIN | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL44 | GENISTEIN | IC50 | = | 190000.0 | nM | - |