Assay Detail
ADMET
CHEMBL1070683
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Cytotoxicity against human KB cells after 72 hrs by MTS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial acridines: synthesis, in vitro activity against P. falciparum and interaction with hematin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.63 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90496 | — | — | 1 | 7.30 |
| CHEMBL524771 | — | — | 1 | 6.22 |
| CHEMBL3216196 | — | — | 1 | 6.16 |
| CHEMBL596013 | — | — | 1 | 6.10 |
| CHEMBL593717 | — | — | 1 | 6.07 |
| CHEMBL596242 | — | — | 1 | 5.68 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 4.65 |
| CHEMBL611636 | — | — | 1 | 4.28 |
| CHEMBL594860 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90496 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL524771 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3216196 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL596013 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL593717 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL596242 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL611636 | — | IC50 | = | 52900.0 | nM | 4.28 |
| CHEMBL594860 | — | IC50 | = | 60100.0 | nM | 4.22 |