Assay Detail
Binding
CHEMBL1070688
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Binding affinity to human adenosine A3 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.21 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201706 | — | — | 1 | 9.55 |
| CHEMBL200732 | — | — | 1 | 9.42 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 9.00 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201706 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL200732 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.4 | nM | 8.85 |