Assay Detail
Binding
CHEMBL1070693
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Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.12 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522152 | — | — | 1 | 9.60 |
| CHEMBL201706 | — | — | 1 | 9.55 |
| CHEMBL200732 | — | — | 1 | 9.42 |
| CHEMBL596042 | — | — | 1 | 9.38 |
| CHEMBL595569 | — | — | 1 | 9.01 |
| CHEMBL611359 | — | — | 1 | 9.01 |
| CHEMBL119709 | IB-MECA | — | 1 | 9.00 |
| CHEMBL606630 | — | — | 1 | 8.98 |
| CHEMBL594625 | — | — | 1 | 8.93 |
| CHEMBL608680 | — | — | 1 | 8.92 |
| CHEMBL594619 | — | — | 1 | 8.87 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.85 |
| CHEMBL596460 | — | — | 1 | 8.67 |
| CHEMBL603424 | — | — | 1 | 8.67 |
| CHEMBL596014 | — | — | 1 | 8.52 |
| CHEMBL603643 | — | — | 1 | 7.81 |
| CHEMBL604790 | — | — | 1 | 7.51 |
| CHEMBL595117 | — | — | 1 | 7.45 |
| CHEMBL593958 | — | — | 1 | 7.21 |
| CHEMBL596027 | — | — | 1 | 7.02 |
| CHEMBL596269 | — | — | 1 | 7.01 |
| CHEMBL594577 | — | — | 1 | 6.95 |
| CHEMBL593445 | — | — | 1 | 6.94 |
| CHEMBL593468 | — | — | 1 | 6.87 |
| CHEMBL593724 | — | — | 1 | 6.84 |
| CHEMBL595987 | — | — | 1 | 6.36 |
| CHEMBL594620 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522152 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL201706 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL200732 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL596042 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL595569 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL611359 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL606630 | — | Ki | = | 1.04 | nM | 8.98 |
| CHEMBL594625 | — | Ki | = | 1.17 | nM | 8.93 |
| CHEMBL608680 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL594619 | — | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL596460 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL603424 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL596014 | — | Ki | = | 3.03 | nM | 8.52 |
| CHEMBL603643 | — | Ki | = | 15.6 | nM | 7.81 |
| CHEMBL604790 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL595117 | — | Ki | = | 35.4 | nM | 7.45 |
| CHEMBL593958 | — | Ki | = | 61.1 | nM | 7.21 |
| CHEMBL596027 | — | Ki | = | 94.9 | nM | 7.02 |
| CHEMBL596269 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL594577 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL593445 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL593468 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL593724 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL595987 | — | Ki | = | 433.0 | nM | 6.36 |
| CHEMBL594620 | — | Ki | = | 1200.0 | nM | 5.92 |