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Assay Detail

CHEMBL1070699

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against Plasmodium falciparum D6 infected in RBCs by parasitic LDH release assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers.
Slade D, Galal AM, Gul W, Radwan MM, Ahmed SA, Khan SI, Tekwani BL, Jacob MR, Ross SA, Elsohly MA.
Bioorg Med Chem (2009) 17 : 7949 -7957
PubMed 19879765 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.82 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL593923 1 8.52
CHEMBL445526 1 8.28
CHEMBL611024 1 8.24
CHEMBL595042 1 8.21
CHEMBL611025 1 8.20
CHEMBL593164 1 8.17
CHEMBL595985 1 8.10
CHEMBL593922 1 7.95
CHEMBL611027 1 7.93
CHEMBL611329 1 7.93
CHEMBL307261 ARTENIMOL 3.0 1 7.83
CHEMBL520530 ANHYDRODIHYDROARTEMISININ 1 7.80
CHEMBL596182 1 7.68
CHEMBL611026 1 7.62
CHEMBL269671 ARTEMISININ 3.0 1 7.48
CHEMBL76 CHLOROQUINE 4.0 1 7.38
CHEMBL593924 1 7.36
CHEMBL611328 1 7.34
CHEMBL593974 1 6.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL593923 IC50 = 3.0 nM 8.52
CHEMBL445526 IC50 = 5.3 nM 8.28
CHEMBL611024 IC50 = 5.8 nM 8.24
CHEMBL595042 IC50 = 6.2 nM 8.21
CHEMBL611025 IC50 = 6.3 nM 8.20
CHEMBL593164 IC50 = 6.7 nM 8.17
CHEMBL595985 IC50 = 7.9 nM 8.10
CHEMBL593922 IC50 = 11.2 nM 7.95
CHEMBL611027 IC50 = 11.7 nM 7.93
CHEMBL611329 IC50 = 11.8 nM 7.93
CHEMBL307261 ARTENIMOL IC50 = 14.8 nM 7.83
CHEMBL520530 ANHYDRODIHYDROARTEMISININ IC50 = 15.8 nM 7.80
CHEMBL596182 IC50 = 20.9 nM 7.68
CHEMBL611026 IC50 = 24.2 nM 7.62
CHEMBL269671 ARTEMISININ IC50 = 32.9 nM 7.48
CHEMBL76 CHLOROQUINE IC50 = 41.6 nM 7.38
CHEMBL593924 IC50 = 43.8 nM 7.36
CHEMBL611328 IC50 = 45.5 nM 7.34
CHEMBL593974 IC50 = 298.3 nM 6.53