Assay Detail
Binding
CHEMBL1070753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR1 after 80 mins by radiometric protein kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.10 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | — | 1 | 7.26 |
| CHEMBL597492 | — | — | 1 | 7.16 |
| CHEMBL605957 | — | — | 1 | 7.14 |
| CHEMBL606168 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL597492 | — | IC50 | = | 69.4 | nM | 7.16 |
| CHEMBL605957 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL606168 | — | IC50 | = | 150.0 | nM | 6.82 |