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Assay Detail

CHEMBL1070770

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat intestinal alpha-glucosidase after 5 mins by spectrophotometry
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

alpha-Glucosidase inhibitory antihyperglycemic activity of substituted chromenone derivatives.
Raju BC, Tiwari AK, Kumar JA, Ali AZ, Agawane SB, Saidachary G, Madhusudana K.
Bioorg Med Chem (2010) 18 : 358 -365
PubMed 19932027 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.29 4.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL591274 1 4.55
CHEMBL590094 1 4.43
CHEMBL590338 1 4.42
CHEMBL590095 1 4.39
CHEMBL589414 1 4.35
CHEMBL590320 1 4.31
CHEMBL590337 1 4.28
CHEMBL592475 1 4.28
CHEMBL592474 1 4.28
CHEMBL589111 1 4.28
CHEMBL591670 1 4.24
CHEMBL590785 1 4.16
CHEMBL155103 1 4.04
CHEMBL605821 1 4.02
CHEMBL592476 1 -
CHEMBL585884 1 -
CHEMBL589883 1 -
CHEMBL590319 1 -
CHEMBL271516 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL591274 IC50 = 28200.0 nM 4.55
CHEMBL590094 IC50 = 37200.0 nM 4.43
CHEMBL590338 IC50 = 37600.0 nM 4.42
CHEMBL590095 IC50 = 40500.0 nM 4.39
CHEMBL589414 IC50 = 44500.0 nM 4.35
CHEMBL590320 IC50 = 49000.0 nM 4.31
CHEMBL590337 IC50 = 53100.0 nM 4.28
CHEMBL592475 IC50 = 52600.0 nM 4.28
CHEMBL592474 IC50 = 52200.0 nM 4.28
CHEMBL589111 IC50 = 52900.0 nM 4.28
CHEMBL591670 IC50 = 58100.0 nM 4.24
CHEMBL590785 IC50 = 68700.0 nM 4.16
CHEMBL155103 IC50 = 91000.0 nM 4.04
CHEMBL605821 IC50 = 96400.0 nM 4.02
CHEMBL592476 IC50 = 111500.0 nM -
CHEMBL585884 IC50 = 185900.0 nM -
CHEMBL589883 IC50 = 128300.0 nM -
CHEMBL590319 IC50 = 104600.0 nM -
CHEMBL271516 IC50 = 242800.0 nM -