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Assay Detail

CHEMBL1070828

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Functional
Agonist activity at rat P2Y6 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type 1321-N1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 6 (CHEMBL3543)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

5-OMe-UDP is a potent and selective P2Y(6)-receptor agonist.
Ginsburg-Shmuel T, Haas M, Schumann M, Reiser G, Kalid O, Stern N, Fischer B.
J Med Chem (2010) 53 : 1673 -1685
PubMed 20095577 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.89 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL214698 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL214698 EC50 = 130.0 nM 6.89