Assay Detail
Functional
CHEMBL1070937
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Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.34 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597204 | — | — | 1 | 5.62 |
| CHEMBL597607 | — | — | 1 | 5.61 |
| CHEMBL597205 | — | — | 1 | 5.59 |
| CHEMBL604804 | — | — | 1 | 5.55 |
| CHEMBL598227 | — | — | 1 | 5.45 |
| CHEMBL598852 | — | — | 1 | 5.42 |
| CHEMBL598022 | — | — | 1 | 5.34 |
| CHEMBL597010 | — | — | 1 | 5.29 |
| CHEMBL597407 | — | — | 1 | 5.24 |
| CHEMBL599457 | — | — | 1 | 5.08 |
| CHEMBL600669 | — | — | 1 | 5.01 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 4.92 |
| CHEMBL598023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597204 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL597607 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL597205 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL604804 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL598227 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL598852 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL598022 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL597010 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL597407 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL599457 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL600669 | — | IC50 | = | 9660.0 | nM | 5.01 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 11880.0 | nM | 4.92 |
| CHEMBL598023 | — | IC50 | > | 50000.0 | nM | - |