Assay Detail
Functional
CHEMBL1071207
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Cytotoxicity against human MDA-MB-231 cells after 96 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.17 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593599 | — | — | 1 | 6.22 |
| CHEMBL593597 | — | — | 1 | 6.10 |
| CHEMBL611341 | — | — | 1 | 6.00 |
| CHEMBL611622 | — | — | 1 | 5.40 |
| CHEMBL550348 | DEFERASIROX | 4.0 | 1 | 5.40 |
| CHEMBL593598 | — | — | 1 | 4.40 |
| CHEMBL595935 | — | — | 1 | 4.40 |
| CHEMBL593132 | — | — | 1 | 4.30 |
| CHEMBL595934 | — | — | 1 | 4.30 |
| CHEMBL609854 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593599 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL593597 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL611341 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL611622 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL550348 | DEFERASIROX | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL593598 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL595935 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL593132 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL595934 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL609854 | — | IC50 | = | 150000.0 | nM | - |