Assay Detail
Functional
CHEMBL1071228
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Increase in cellular triglyceride level in human HepG2 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.94 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612007 | — | — | 1 | 7.38 |
| CHEMBL611735 | — | — | 1 | 7.19 |
| CHEMBL605314 | — | — | 1 | 7.14 |
| CHEMBL612006 | — | — | 1 | 6.89 |
| CHEMBL62136 | T091317 | — | 1 | 6.86 |
| CHEMBL595689 | — | — | 1 | 6.83 |
| CHEMBL611465 | — | — | 1 | 6.64 |
| CHEMBL594757 | — | — | 1 | 6.57 |
| CHEMBL595937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612007 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL611735 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL605314 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL612006 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL62136 | T091317 | EC50 | = | 137.0 | nM | 6.86 |
| CHEMBL595689 | — | EC50 | = | 147.0 | nM | 6.83 |
| CHEMBL611465 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL594757 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL595937 | — | EC50 | - | — | - |