Assay Detail
Binding
CHEMBL1071575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK2 C163S mutant by isothermal calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.13 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL599111 | — | — | 1 | 5.72 |
| CHEMBL611079 | — | — | 1 | 5.38 |
| CHEMBL609039 | — | — | 1 | 5.14 |
| CHEMBL508280 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL599111 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL611079 | — | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL609039 | — | Kd | = | 7200.0 | nM | 5.14 |
| CHEMBL508280 | — | Kd | = | 51100.0 | nM | 4.29 |